文献类型： 外文期刊
作者： Gao, Li Wen 1 ; Li, Wan Yi 2 ; Zhao, Yi Lu 1 ; Wang, Jian Wen 1 ;
作者机构： 1.Soochow Univ, Sch Pharmaceut Sci, Suzhou 215006, Peoples R China
2.Yunnan Acad Agr Sci, Inst Med Plants, Kunming 650223, Peoples R China
关键词： Armillaria mellea;cultivation;chemical constituents;pharmacological effect
期刊名称：AFRICAN JOURNAL OF BIOTECHNOLOGY （ 影响因子：0.573； 五年影响因子：0.794 ）
ISSN： 1684-5315
年卷期： 2009 年 8 卷 25 期
页码：
收录情况： SCI
摘要： Armillaria mellea, a symbiotic fungus in the underground tubers of Chinese medicinal orchid Gastrodia elata, is one of the main biological active components and pharmaceutical effects of its host gastrodia. The purpose of this review is to bring attention to the biological properties of this unique A. mellea mushroom and its constituents, as well as to suggest the potential for the development of new drugs related to this fungus. It contains various known and untapped bioactive metabolites such as polysaccharides, sesquiterpene aryl esters, steroids and fibrinolytic enzymes. It could be exploited as an important source of new biological natural products with anticonvulsant, immunomodulatory and antimicrobial functions. The batch culture is preferred as an alternative means of getting bioactive components from Armellaria fermentation. Challenges in investigations on A. mellea include the optimization of culture parameters, the further elucidation of the molecular pharmacological mechanism and relationship between structure and function of their secondary metabolites.
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